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2 edition of synthesis of 2-arylbenzofurans found in the catalog.

synthesis of 2-arylbenzofurans

Joshua M. Kielty

synthesis of 2-arylbenzofurans

by Joshua M. Kielty

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Published by University College Dublin in Dublin .
Written in English


Edition Notes

Statementby Joshua M. Kielty.
ContributionsUniversity College Dublin. Department of Chemistry.
The Physical Object
Pagination(2), v, 192, (9)p. :
Number of Pages192
ID Numbers
Open LibraryOL18233212M

  The heterocyclic compound 2-arylbenzofurans consists of fused benzene and furan rings along with different substituted groups (complex structures) at the C-2 position. These compounds show a wide range of pharmacological properties including anticancer [ 5 ], antibacterial [ 6 ], antimicrobial [ 7 ], antifungal [ 8 ], anticonvulsant [ 9 ], anti. Derivatives such as 3-unsubstituted 2-arylbenzofurans often have biological activities such as anticancer, antimicrobial, and antioxidant properties. However, methods for their synthesis are often complex, involve the use of expensive reagents or catalysts, or have low yields.

MAO inhibitory activity of 2-arylbenzofurans versus 3-arylcoumarins: synthesis, in vitro study and docking calculations (Ferino G, Cadoni E, Matos MJ*, Quezada E, Uriarte E, Santana L, Vilar S, Tatonetti NP, Yáñez M, Viña D, Picciau C, Serra S, Delogu G*) ChemMedChem , 8, doi: /cmdc   Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells Hak Ju Lee, Da Hyun Lyu, Uk Koo, Sung-Jin Lee .

CiteScore: ℹ CiteScore: CiteScore measures the average citations received per peer-reviewed document published in this title. CiteScore values are based on citation counts in a range of four years (e.g. ) to peer-reviewed documents (articles, reviews, conference papers, data papers and book chapters) published in the same four calendar years, divided by the number of. Synthesis of Aryl-3a, 9-dihydro-1H, 3H-furo[4,3-b][1,5]benzothiazepinones Full Text: CiNii Binding of Sulfonamides to Erythrocyte Proteins and Possible Drug-Drug Interaction Full Text: CiNii.


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Synthesis of 2-arylbenzofurans by Joshua M. Kielty Download PDF EPUB FB2

An environmentallyfriendly one-pot synthesis of 2-arylbenzofurans under ambient temperature has been developed. It features an ortho-hydroxyl group assisted Wittig reaction of substituted salicylaldehyde followed by an in situ oxidative cyclization. Its advantages include readily available and non-hazardous Jump to main content.

A novel two-step synthesis of 2-arylbenzofurans has been developed. It involves a selective cross McMurry coupling of a salicylaldehyde or substituted salicylaldehyde with an aromatic aldehyde and a sequential oxidative cyclization of the resulting by: Abstract An alternative route for the synthesis of 2-arylbenzofurans is described by iodine (III)-catalyzed oxidative cyclization of 2-hydroxystilbenes using 10 mol% (diacetoxyiodo)benzene [PhI (OAc) 2] as catalyst in the presence of m -chloroperbenzoic acid.

The Cited by: 3. The first example of the palladium-catalyzed one-pot synthesis of 2-arylbenzofurans in moderate to excellent yields via a tandem reaction of 2-hydroxyarylacetonitriles with sodium sulfinates is reported.

A plausible mechanism for the formation of 2-arylbenzofurans involving desulfinative addition and intramolecular annulation reactions is by: Related Books SoS C-1 Building Blocks in Organic Synthesis SoS Multicomponent Reactions SoS Cross Coupling and Heck-Type Reactions SoS Asymmetric Organocatalysis SoS Water in Organic Synthesis A Convenient Two-Step Synthesis of 2-Arylbenzofurans Full Text.

see article for more reactions. Abstract. An iodine(III)-catalyzed oxidative cyclization of 2-hydroxystilbenes using 10 mol% (diacetoxyiodo)benzene [PhI(OAc)2] as catalyst in the presence of m-chloroperbenzoic acid provides 2-arylbenzofurans in good to excellent yields.

see article for more examples. Related Books SoS C-1 Building Blocks in Organic Synthesis SoS Multicomponent Reactions SoS Cross Coupling and Heck-Type Reactions (III)-Catalyzed Synthesis of 2-Arylbenzofurans Full Text HTML PDF ( kb) Supporting Information Melnykov, Kostiantyn P.

Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Several approaches have been reported for the construction of benzofurans and naphthofurans. Recently, Singh and Writh utilized DIB-promoted metal-free cyclization of o-hydroxystilbenes to prepare 2-arylbenzofurans (Scheme 40).

Palladium-Catalyzed Reaction of Arylboronic Acids with Aliphatic Nitriles: Synthesis of Alkyl Aryl Ketones and 2-Arylbenzofurans Xingyong Wang, Xiaodong Wang, Miaochang Liu*, Jinchang Ding, Jiuxi Chen*, Huayue Wu *College of Chemistry and Materials Engineering, Wenzhou University, WenzhouChina, Email: mcljiuxichen An alternative copper source, [Cu(phen)(Ph 3 P) 2]NO 3, again in combination with Cs 2 CO 3, is especially suited to the synthesis of 2-arylbenzofurans (; R = Ar) from iodophenols and aryl alkynes (OL, OL).

A Facile Two-Step Synthesis of 2-Arylbenzofurans Based on the Selective Cross McMurry Couplings. The Journal of Organic Chemistry72 (26), DOI: /jo Fu-Qiang Shi, Xin Li, Yuanzhi Xia, Liming Zhang, and, Zhi-Xiang Yu.

Book. Jan ; Francis A. Carey A new and efficient synthesis of 2-arylbenzofurans has been achieved via a route involving acylation and subsequent [3,3]-sigmatropic rearrangement of oxime.

In summary, a series of novel benzofuran derivatives containing biaryl moiety were designed and synthesized. This work establishes that 2- (4-bromophenyl)benzofuran are suitable substrates for Suzuki cross-coupling reactions with relevant arylboronic acids.

Starting from 2-hydroxybenzyl alcohol, a series of 2-arylbenzofurans have been synthesized and evaluated as acetylcholinesterase inhibitors at 23 &# 1. Introduction. 2-Arylbenzo[b]furan moiety is a common structural subunit found in natural products [1,2,3] and synthetic compounds with important biological activities [4,5,6,7].For example, a representative complex of the natural 3-deformylated 2-arylbenzo[b]furan is ailanthoidol in (Figure 1, 1), which was isolated from the chloroform-soluble fraction of the tree of Zanthoxylum.

A tale of two scaffolds: Herein we describe the synthesis, in vitro inhibition of MAO‐A and MAO‐B, reversibility studies, and docking calculations for two groups of 2‐arylbenzofurans and 3‐arylcoumarins. A comparative study of both scaffolds was performed. A tale of two scaffolds: Herein we describe the synthesis, in vitro inhibition of MAO‐A and MAO‐B, reversibility studies, and docking calculations for two groups of 2‐arylbenzofurans and 3‐arylcoumarins.

A comparative study of both scaffolds was performed. An alternative route for the synthesis of 2-arylbenzofurans without the use of Pd catalyst is described by iodine(III)-catalyzed oxidative cyclization of 2-hydroxystilbenes, using 10 mol% (diacetoxyiodo)benzene [PhI(OAc) 2] as catalyst in the presence of m-chloroperbenzoic acid.

The 2-arylbenzofurans were isolated in good-to-excellent yields. Related Books SoS C-1 Building Blocks in Organic Synthesis SoS Multicomponent Reactions Stereoselective Synthesis of (+)epi-Goniofufurone and Analogues Synthesis of Alkyl Aryl Ketones and 2-Arylbenzofurans Full Text.

A tandem chemoselective synthesis of 2-arylbenzofurans was accomplished from o-hydroxy-gem-(dibromovinyl)benzenes and BiAr3 reagents under palladium-catalyzed conditions. The book then explores catalyzed procedures for benzofuran synthesis in greater detail and depth than is currently available in published review articles.

This volume is part of the short series authored by Xiao-Feng Wu that summarizes recent achievements on heterocycle synthesis with transition metals as catalysts, with each volume dedicated.(c) Kaur, N.

Application of microwave-assisted synthesis in the synthesis of fused six-membered heterocycles with N-heteroatom. Synth. Commun.,45, In vivo imaging of β-amyloid plaques in the brain may lead to the early diagnosis of Alzheimer’s disease (AD) and monitoring of the progression and effectiveness of treatment.

In the present study, we report on the development of two potential PET probes, [18F]FPYBF-2 ([18F]10) and [18F]FPHBF-2 ([18F]21), for imaging of β-amyloid plaques in AD brain.